association between menstruation signs and anxiety, depression, and stress in school girls in mashhad in 2011-2012

background: menstruation signs are among the most common disorders in adolescents and are influenced by various environmental and psychosocial factors. this study aimed to define the association between menstruation signs and anxiety, depression, and stress in school girls in mashhad in 2011-2012. materials and methods: this was a cross-sectional study on 407 high school girls in mashhad who were selected through two-step random sampling. the students completed a questionnaire concerning demographic characteristics, menstruation, depression, anxiety, and stress scale of 21 questions (dass-21), and menstruation signs in three phases of their menstruation. data were analyzed by the statistical tests of pearson correlation coefficient, student’s t -test, one-way analysis of variance (anova), and regression through spss version 14. results: based on the findings, 74% of the subjects reported pre-menstruation signs, 94% reported signs during bleeding, and 40.8% reported post-menstruation signs. about 44.3% of the subjects had anxiety, 45.5% had depression, and 47.2% had stress. in addition, pearson correlation coefficient test showed a significant positive correlation between menstruation signs and depression, anxiety, and stress ( p < 0.05). conclusion: with regard to the association between menstruation signs and psycho-cognitive variables, prevention and treatment of these disorders by the authorities of education and training and the ministry of health are essential.